Grazia Ambrosini Selected Research

sotrastaurin

11/2021	A Phase Ib Study of Sotrastaurin, a PKC Inhibitor, and Alpelisib, a PI3Kα Inhibitor, in Patients with Metastatic Uveal Melanoma.
5/2014	The phosphoinositide 3-kinase α selective inhibitor BYL719 enhances the effect of the protein kinase C inhibitor AEB071 in GNAQ/GNA11-mutant uveal melanoma cells.

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Grazia Ambrosini Research Topics

Disease

16	Neoplasms (Cancer) 01/2021 - 06/2006
14	Uveal melanoma 01/2022 - 01/2012
6	Melanoma (Melanoma, Malignant) 11/2021 - 01/2012
4	Neoplasm Metastasis (Metastasis) 01/2022 - 12/2013
2	Liposarcoma 02/2009 - 07/2007
1	Disease Progression 06/2014
1	Colorectal Neoplasms (Colorectal Cancer) 08/2009
1	Polyploidy 04/2009
1	Colonic Neoplasms (Colon Cancer) 02/2009
1	Malaria 02/2009
1	Neurofibrosarcoma (MPNST) 04/2008
1	Neurofibromatosis 1 (Neurofibromatosis Type I) 04/2008
1	Chromosome Aberrations (Chromosome Abnormalities) 07/2007
1	Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor) 06/2006
1	Weight Gain 05/2004
1	Hypoxia (Hypoxemia) 09/2002

Drug/Important Bio-Agent (IBA)

5	Proteins (Proteins, Gene)FDA Link 01/2020 - 09/2002
5	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 08/2014 - 04/2008
4	Pharmaceutical PreparationsIBA 01/2019 - 07/2007
4	AZD 6244IBA 08/2014 - 01/2012
4	Mitogen-Activated Protein KinasesIBA 06/2014 - 04/2008
3	GTP-Binding Proteins (G-Protein)IBA 08/2014 - 07/2012
2	sotrastaurinIBA 11/2021 - 05/2014
2	AlpelisibIBA 11/2021 - 05/2014
2	PLX51107IBA 01/2019 - 01/2019
2	RNA (Ribonucleic Acid)IBA 01/2019 - 09/2002
2	Adenosine Triphosphate (ATP)IBA 06/2014 - 01/2012
2	Phosphatidylinositols (Phosphatidylinositol)IBA 05/2014 - 01/2012
2	Biological ProductsIBA 07/2012 - 07/2007
2	Irinotecan (Camptosar)FDA LinkGeneric 08/2009 - 04/2008
2	Cyclin-Dependent Kinases (cdk Proteins)IBA 04/2009 - 04/2008
2	alvocidib (flavopiridol)IBA 04/2008 - 06/2006
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2022
1	CytokinesIBA 01/2022
1	Macrophage Migration-Inhibitory FactorsIBA 01/2022
1	Interleukin-6 (Interleukin 6)IBA 01/2021
1	Immune Checkpoint InhibitorsIBA 01/2021
1	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA 01/2019
1	AZD4547IBA 01/2019
1	ChromatinIBA 10/2015
1	(+)-JQ1 compoundIBA 10/2015
1	ras ProteinsIBA 08/2014
1	Temozolomide (Temodar)FDA LinkGeneric 06/2014
1	Dacarbazine (DIC)FDA LinkGeneric 06/2014
1	Protein Kinase CIBA 05/2014
1	LuciferasesIBA 12/2013
1	Anaplastic Lymphoma KinaseIBA 12/2013
1	CrizotinibIBA 12/2013
1	MAP Kinase Kinase Kinases (MAP Kinase Kinase Kinase)IBA 07/2012
1	MitogensIBA 07/2012
1	TOR Serine-Threonine KinasesIBA 01/2012
1	Phosphotransferases (Kinase)IBA 01/2012
1	(5- (2,4- bis((3S)- 3- methylmorpholin- 4- yl)pyrido(2,3- d)pyrimidin- 7- yl)- 2- methoxyphenyl)methanolIBA 01/2012
1	Heterotrimeric GTP-Binding Proteins (Heterotrimeric G-Proteins)IBA 01/2012
1	Proteasome Endopeptidase Complex (Proteasome)IBA 08/2009
1	Small Interfering RNA (siRNA)IBA 04/2009
1	2- ((3- ((4- ((5- (2- ((3- fluorophenyl)amino)- 2- oxoethyl)- 1H- pyrazol- 3- yl)amino)quinazolin- 7- yl)oxy)propyl)(ethyl)amino)ethyl dihydrogen phosphateIBA 04/2009
1	chloroquine diphosphate FDA LinkGeneric 02/2009
1	Phosphatidylinositol 3-Kinases (PI 3 Kinase)IBA 02/2009
1	safingol (sphinganine)IBA 02/2009
1	Cyclin D1IBA 04/2008
1	Type I DNA Topoisomerases (Topoisomerase I)IBA 04/2008
1	trioctyl phosphine oxide (TOPO)IBA 04/2008
1	PoisonsIBA 04/2008
1	Sorafenib (BAY 43-9006)FDA Link 04/2008
1	nutlin 3IBA 07/2007
1	Imatinib Mesylate (Gleevec)FDA Link 06/2006
1	LigandsIBA 06/2006
1	GhrelinIBA 05/2004
1	Deferoxamine (Desferal)FDA LinkGeneric 09/2002
1	Complementary DNA (cDNA)IBA 09/2002
1	Erythropoietin FDA Link 09/2002
1	Messenger RNA (mRNA)IBA 09/2002
1	Hypoxia-Inducible Factor 1IBA 09/2002
1	LeptinIBA 09/2002
1	cobaltous chloride (cobalt(II)chloride)IBA 09/2002

Therapy/Procedure

10	Therapeutics 01/2019 - 04/2008
4	Drug Therapy (Chemotherapy) 06/2014 - 04/2008
1	Adjuvant Chemotherapy 01/2022
1	Injections 12/2013
1	Transplantation 12/2013